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EVALUATION OF WOUND HEALING, ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITIES IN LEAF EXTRACT OF BECIUM GRANDIFLORUM L. [Abstract ID: 1207-03]
Based on traditional claims, leaves of Becium grandiflorum were investigated for their potential wound healing activity using excision and incision wound models. In addition histological analysis, anti-inflammatory and antibacterial activities of the leaves were performed. Wound healing activity was studied by topical application of simple ointment of the leaf extract at a concentration of 5% and 10% (w/w) after it was extracted by maceration using 70% ethanol. Toxicity of the formulated ointments was studied by a skin irritation test on Swiss albino mice. For the anti-inflammatory study, the carrageenan-induced hind paw edema model was used at a concentration of 100, 200 and 400 mg/kg. The antibacterial activity of the extract was examined using disk diffusion technique against several pathogenic bacterial strains that commonly occurr in wounds at a concentration of 50, 100 and 200 µg/µl.b. The ointment formulation of the extract was found to be non-irritant at 5% concentration. However, continuous application of 10% showed skin irritation. Treatment of the wound with the ointments exhibited significant (p< 0.001) increase in wound contraction rate, shorter epithelization time, higher skin tensile strength that was supported by considerable deposition of collagen, fibroblast proliferation and vascularization form histological analysis. The plant extract also showed significant (p